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Time to Weight Loss and Subsequent Weight Maintenance: A Survival Analysis

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This study explores the temporal aspects of the weight loss process within the framework of time-to-event analysis (Survival analysis) using data from a Randomized Controlled Trial (RCT) in a weight control program. The experiment includes 418 participants (206 in the treated group and 212 in the control group) across two clinical sites (South Carolina and Vermont) and comprises two main phases: the initial weight loss phase (months 1-6) and the subsequent weight maintenance phase (months 7-18). Participants randomized into the treated group receive financial incentives based on their behaviors and outcomes during the study.

For the weight loss phase, we investigate whether and how much financial incentives are effective in reducing the duration to achieve weight loss and which participants benefit most from incentive structures. For the weight maintenance phase, we explore whether faster weight losers maintain better long-term outcomes and what long-term weight outcomes would look like under alternative intervention designs. Our analytical framework combines multiple complementary causal inference approaches to address identification challenges. We employ Cox models to estimate average treatment effects, causal survival forests to identify individual-level treatment effects, principal stratification analysis to estimate the effect of weight loss achievement time on weight maintenance duration, and sequential G-estimation to simulate counterfactual policy scenarios to measure the effects of alternative incentive timing strategies.

Our findings reveal that financial incentives increase the probability of achieving weight loss by approximately 37% at any given time, with substantial treatment effect heterogeneity across participants. Participants with higher baseline BMI demonstrate systematically larger benefits from financial incentives. Our weight maintenance analysis reveals that participants who become "fast weight losers" only under treatment conditions experience significantly longer maintenance benefits. Finally, our counterfactual analysis reveals that behavioral incentives combined with outcome incentives provide significantly higher success rates for weight maintenance than outcome incentives alone.

Our findings offer actionable policy recommendations for optimizing weight control interventions. Healthcare systems should prioritize targeting individuals with higher baseline BMI with financial incentives and develop comprehensive intervention designs combining behavioral incentives with outcome incentives for significantly higher success rates than outcome incentives alone.

Works in progress

- The Role of Motivations in Weight Outcomes: An RCT Study [AI-Generated Podcast by NotebookLM]

- Machine Learning for Breast Cancer Stage Prediction in Claims Data: A SEER-Medicare Study

- The Social Determinants of Health: A new approach

Peer-Reviewed Publications and Submitted Works

- An Exploratory Analysis of Patterns of Weight Change in a Post-Cessation Weight Management Trial (published at "Nicotine & Tobacco Research", May 2025) [AI-Generated Podcast by NotebookLM]

- Machine Learning-Driven Insights into the Structural and Socioeconomic Predictors of Top Five Cancer Mortality Rates in the U.S.

- Impact of Treatment Delays on Healthcare Costs in Patients with Breast Cancer: A Mediation Analysis of Healthcare Utilization by Socioeconomic Status

- Disparities in Treatment Delay and Its Trends

- Abstention and Unconditional Cash Transfer Effects on the Tobacco Consumption: Evidence from Iran's Energy Subsidy Reform 2010 (presented at Fourth International Conference on the Iranian Economy, 2016)

Other Works and Published Reports

- A Portrait of Multidimensional Poverty in Iran, November 2020.

- Analysis of Household Expenditures and Income Data on 2019: Average Caloric Requirements of Iranian Households, July 2020.

- Examining executive considerations, inflationary effects and recovery consequences of gasoline price increase, November 2019.

- Alternative Support Policy for Preferential Exchange Rate, May 2019.

- Estimation of premiums' elasticities in Iran by using QUAIDS, June 2018.

- Estimation of the seasonal poverty line in Iran, December 2018.

- An overview of the expanded CBN method to calculate Iran's poverty line in 2016, November 2018.

- Premiums' placement on Iranian households' budget, April 2017.